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Turell L, Radi R, Alvarez B

Histidine tags have strong affinity for metal ions

Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression

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Think of this preparation phase as creating the optimal internal environment for the peptide to work effectively

As previously described, perinatal dietary transitions often induce ruminal dysbiosis, which compromises glucogenic precursor supply and promotes extensive fat mobilization, thereby leading to excessive ketone body production in the liver